Human chorionic gonadotropin is an immune modulator and can prevent autoimmune diabetes in NOD mice
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چکیده
منابع مشابه
Transient upregulation of IDO in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes
Objective: Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of pre-existing autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigate the role of a key pregnancy hormone, human chorionic gonadotropin (hCG), in immune tolerance against autoimmune...
متن کاملTransient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes.
OBJECTIVE Pregnancy induces a state of immunological tolerance that aims at suppressing immune responses against the fetus and has been linked to temporal remission of preexisting autoimmune disorders. To understand the mechanisms of this reversible immune regulation, we investigated the role of a key pregnancy hormone, human chorionic gonadotropin (hCG), in immune tolerance against autoimmune ...
متن کاملHuman Chorionic Gonadotropin
A highly active preparation of human chorionic gonadotropin has been obtained by simple methods of column chromatography on diethylaminoethyl Sephadex and Sephadex G-100. The preparation appeared homogeneous by disc and immunoelectrophoresis, ultracentrifugation, and end group analysis. It assayed at 12,000 i.u. per mg by the rat prostrate gland and accessory sex organ method. The ~20,~ value w...
متن کاملInhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
OBJECTIVE The T helper 17 (Th17) population, a subset of CD4-positive T-cells that secrete interleukin (IL)-17, has been implicated in autoimmune diseases, including multiple sclerosis and lupus. Therapeutic agents that target the Th17 effector molecule IL-17 or directly inhibit the Th17 population (IL-25) have shown promise in animal models of autoimmunity. The role of Th17 cells in type 1 dia...
متن کاملCannabidiol arrests onset of autoimmune diabetes in NOD mice.
We have previously reported that cannabidiol (CBD) lowers the incidence of diabetes in young non-obese diabetes-prone (NOD) female mice. In the present study we show that administration of CBD to 11-14 week old female NOD mice, which are either in a latent diabetes stage or with initial symptoms of diabetes, ameliorates the manifestations of the disease. Diabetes was diagnosed in only 32% of th...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2007
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-007-0769-y